Determination of antigenic relationships among legionellae and non-legionellae by direct fluorescent-antibody and immunodiffusion tests.

Journal of Clinical Microbiology
L H OrrisonL Thacker

Abstract

Six isolates, five from water samples and one from a human tracheal swab taken at autopsy, reacted strongly with working dilutions of Legionella fluorescent-antibody conjugates. Of these, two isolates of Pseudomonas fluorescens (EB and CDC93), one isolate of the Flavobacterium-Xanthomonas group (CDC65), and one isolate of P. alcaligenes (CDC11) reacted with Legionella pneumophila serogroup 1 conjugate. P. alcaligenes ABB 50 reacted with an L. pneumophila serogroup 3 conjugate and of P. maltophilia reacted with the L. micdadei conjugate. Antisera and labeled conjugates were prepared for these new cross-reacting isolates, and their relationships to the legionellae were examined by direct fluorescent-antibody and immunodiffusion tests. A nonreciprocal cross-reaction existed between L. micdadei and P. maltophilia and also between serogroups 3 of L. pneumophila and P. alcaligenes ABB50. Of the four isolates that reacted with serogroup 1 of L. pneumophila, P. fluorescens CDC93 had the strongest relationship, and the other three had only minor relationships. Although cross-reactivity among non-legionellae and legionellae has not been a major problem, these findings are relevant to the interpretation of direct fluorescent-antibody test...Continue Reading

References

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Citations

Jul 5, 2002·Clinical Microbiology Reviews·Barry S FieldsRichard E Besser
Jan 3, 2013·FEMS Microbiology Ecology·Wei ZhangAaron I Packman
Nov 1, 1983·Journal of Clinical Microbiology·J R JolyD Ramsay
Dec 1, 1984·Journal of Clinical Microbiology·L H GostingL C Goldstein
Jan 1, 1988·Clinical Microbiology Reviews·W C Winn
Apr 1, 1987·Journal of Clinical Microbiology·R F BensonH W Wilkinson
Mar 1, 1986·Journal of Clinical Microbiology·P H Edelstein
Feb 1, 1986·Journal of Clinical Microbiology·H W WilkinsonB B Plikaytis
Apr 1, 1985·Applied and Environmental Microbiology·R L TyndallR Jernigan
Dec 1, 1991·Applied and Environmental Microbiology·A K BejR M Atlas

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