PMID: 20112729Feb 2, 2010Paper

Determination of apparent oil-water partition coefficient of andrographolide and dehydroandrographolide and effect of pH on them

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Yuan YaoYuan-Er Zeng

Abstract

To determine the apparent n-octanol-water/buffer partition coefficient of andrographolide and dehydroandrographolide. The apparent n-octanol-water/buffer partition coefficients of andrographolide and dehydroandrographolide were measured by shaking flask method. The concentrations of andrographolide and dehydroandrographolide were analyzed by HPLC method. The Papp of andrographolide and dehydroandrographolide were 3.90 (log Papp = 0.59) and 19.75 (log Papp = 1. 30) in water at 37 degrees C, respectively. The apparent n-octanol-buffer partition coefficients of andrographolide and dehydroandrographolide are influenced by pH, and the higher pH may decrease the apparent n-octanol-buffer partition coefficients of them. Andrographolide has the highest partition coefficient in pH6, and dehydroandrogapholide in pH5.

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