Determination of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, in umbilical blood

Metabolism: Clinical and Experimental
Hirokazu TsukaharaMitsufumi Mayumi

Abstract

Endothelial cells produce nitric oxide (NO), a potent vasodilator. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NO synthase. Little is known about the potential physiological roles of ADMA in a perinatal setting. This study measures concentrations of ADMA in umbilical blood using enzyme-linked immunosorbent assay and those of NO as nitrite/nitrate (NOx(-)) using the Griess assay. Their relationship to the degree of prematurity and maternal clinical condition is examined. Results show that ADMA concentrations in umbilical blood from control newborns were about twice as high as those of lactating women, healthy children, and healthy adults. Umbilical blood NOx(-) concentrations from control newborns were about half of those of lactating women, healthy children, and healthy adults. Consequently, the levels of ADMA relative to NOx(-) were about 4-fold higher in umbilical blood from control newborns than in blood from lactating women, healthy children, and healthy adults. Furthermore, the umbilical blood ADMA concentrations and the ratios of ADMA to NOx(-) in newborns were higher according to their birth prematurity and lower birth weight. The umbilical ADMA concentrations were independent of the delivery mode an...Continue Reading

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Citations

Jul 8, 2009·Pediatric Research·Kristin BraekkeAnne Cathrine Staff
Feb 13, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·D U IsikI Cetin
Feb 2, 2010·Early Human Development·Hirokazu Tsukahara, Hironori Nagasaka
Jan 30, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ertac GumusEsra Sahin Gunes
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Oct 9, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Peter ChedrauiTommaso Simoncini
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Mar 2, 2021·Journal of Neonatal-perinatal Medicine·Neveen Tawfik AbedEman Rateb Abd Almonaem
Oct 13, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ei MarutaFumitaka Kikkawa

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