Determination of avermectins: a QuEChERS approach to the analysis of food samples

Food Chemistry
A RúbiesF Centrich

Abstract

We present a simple method for extracting avermectines from meat, based on a QuEChERS approach followed by liquid chromatography (LC) coupled to triple quadrupole (QqQ) tandem mass spectrometry (MS/MS). The compounds considered are ivermectin, abamectin, emamectin, eprinomectin, doramectin and moxidectin. The new method has been fully validated according to the requirements of European Decision 657/2002/CE (EU, 2002). The method is suitable for the analysis of avermectins at concentration as low as 2.5 μg kg(-1), and allows high sample throughput. In addition, the detection of avermectins by high resolution mass spectrometry using a quadrupole-Orbritrap (Q-Orbitrap) hybrid instrument has been explored, and the target Selected Ion Monitoring data dependent MS/MS (t-SIM-dd MS/MS) mode has been found to provide excellent performance for residue determination of target analytes.

References

Aug 3, 2002·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Irina RudikRobert H Poppenga
Sep 5, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Martin DanaherMichael O'Keeffe
Oct 31, 2009·Journal of Separation Science·Koichi InoueHisao Oka
May 21, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Fengmei WangFrank Sen-Chun Lee

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Citations

Jan 19, 2016·Food Chemistry·Jhonyson Arruda Carvalho GuedesRonaldo Ferreira do Nascimento
Apr 3, 2018·Analytical and Bioanalytical Chemistry·Diego Hernando Ângulo FlorezKeyller Bastos Borges
Feb 23, 2021·Critical Reviews in Analytical Chemistry·Xue-Xia JiaZhen-Chuan Fan
Mar 16, 2021·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Kodai BeppuKoichi Inoue

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