PMID: 2508042Jun 1, 1989Paper

Determination of bactericidal minimum concentrations of 3 antiseptics and 1 disinfectant on 580 hospital gram-negative bacilli

Pathologie-biologie
P GirardoJ Fleurette

Abstract

Minimal bactericidal activities (MBCs) of three antiseptics (povidone iodine, chlorhexidine digluconate, benzalkonium chloride) and one disinfectant (sodium hypochloride) where determined, on 580 hospital Gram negative bacilli. Previously the Afnor T 72-150 standard for antiseptic and disinfectant was established for two reference strains E. coli CIP 54 127 and P. aeruginosa CIP A 22. No difference was found between the MBC obtained with these strains in Afnor standard and in microdilution method. Microdilution method allows to test 11 hospital isolates and one reference strain. A strain was considered as resistant when the MBC was one dilution higher than the reference strain MBC. Results were as follows: None strain was resistant to sodium hypochloride and povidone iodine; 18.2% Enterobacteriaceae were resistant to chlorhexidine digluconate with 94.2% of Proteus; 4% of Enterobacteriaceae were resistant to benzalkonium chloride with 89.5% of Proteus and only 1.8% other bacilli. Results obtained in the present study are similar as those previously published particularly with Proteus; nevertheless other studies have reported P. aeruginosa strains resistant to chlorhexidine digluconate and benzalkonium chloride; this last point w...Continue Reading

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.