Determination of bone age in pediatric patients with Crohn's disease should become part of routine care

Inflammatory Bowel Diseases
Neera GuptaEric Vittinghoff

Abstract

Impaired growth and delayed puberty are common in pediatric Crohn's disease (CD). Bone age (BA) is important for interpretation of statural growth. Our aims were to 1) determine the distribution of BA-Z scores; 2) identify clinical factors associated with BA-Z scores; and 3) compare anthropometric Z scores based on chronological age (CA) (CA-Z) versus BA-Z in pediatric CD. CD patients ≤ CA 15 in females and 17 years in males were enrolled in a cross-sectional study. BA was determined with left hand/ wrist x-ray. In all, 49 patients (65% male; 84% Caucasian; mean CA 13 years) examined between January 2007 and July 2009 qualified for the study. Mean BA-Z score was -1.40 ± 1.50 (standard deviation). 41% had BA-Z score < -2.0. Mean BA-Z scores were lower in females (P = 0.02), Caucasians (P = 0.006), Tanner stage 1-3 children (P = 0.004), and patients with colonic disease (P = 0.0006), past corticosteroid exposure (P = 0.01), current azathioprine/6-mercaptopurine treatment (P = 0.003), or lower height (P = 0.006), weight (P < 0.001), or body mass index (BMI) (P = 0.01) CA-Z scores. Mean height, weight, and BMI BA-Z scores were 0.73 units (P < 0.0001), 0.51 units (P < 0.0001), and 0.23 units (P < 0.0001) greater than mean height, we...Continue Reading

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Feb 3, 2011·Inflammatory Bowel Diseases·Neera GuptaEric Vittinghoff
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Citations

May 27, 2014·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Jessica JudgeJoan English
Jul 22, 2014·Journal of Paediatrics and Child Health·Daniel A Lemberg, Andrew S Day
Mar 17, 2017·Inflammatory Bowel Diseases·Thomas D WaltersRoopal B Thakkar
Mar 20, 2020·Inflammatory Bowel Diseases·Neera GuptaCheng-Shiun Leu
Sep 26, 2012·Nature Reviews. Gastroenterology & Hepatology·Thomas D Walters
May 16, 2018·World Journal of Gastroenterology : WJG·Neera GuptaCheng-Shiun Leu
Mar 30, 2021·Frontiers in Pediatrics·Federica CavalloCosimo Giannini

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