Determination of butaperazine in biological fluids by gas chromatography using nitrogen specific detection system

Journal of Chromatographic Science
J I JavaidJ M Davis

Abstract

A simple and sensitive gas chromatographic method for the quantitative determination of butaperazine in biological fluids is described. The use of a nitrogen specific detector reduces the number of interfering peaks, thereby increasing the number of samples that can be analyzed. When butaperazine is extracted from 2 ml of plasma, the coefficient of variation is 7.4% over the concentration range of 5-180 ng/ml. The method was used to measure the levels in plasma and red blood cells in schizophrenic patients treated with butaperazine. It was also extended to measure butaperazine levels in rat red blood cells, plasma, liver, and brain after intraperitoneal injection (15 mg/kg).

Citations

Jan 1, 1984·Psychiatry Research·G K RavichandranR C Smith
Apr 1, 1985·Biopharmaceutics & Drug Disposition·M E WolfJ M Davis

Related Concepts

Metazoa
Brain Chemistry
Chromatography, Gas-Liquid
Erythrocytes
Liver
Phenothiazines
Fresh Frozen Plasma
Rats, Laboratory

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