Abstract
A study of plasma and cardiac concentrations of amiodarone during the course of long-term oral therapy was made possible by the improvement of analytical high performance liquid chromatography of plasma and tissue extracts. The plasma level was found to increase linearly with the daily dose of the drug, above a threshold value of c. 1 . 9 mg kg-1 day-1. Similarly, the cardiac content increased linearly with the daily dose, with no threshold, showing that the drug is taken up and accumulated in the cardiac tissue, with no obvious difference between atrial and ventricular samples (P greater than 0 . 05). Both plasma and heart showed no saturation at high drug intake, a justification for increasing the oral intake in severe cases. The linear relationship between tissue and blood concentrations allows a prediction of the cardiac level from a simple and routine blood analysis.
References
Dec 1, 1976·The American Journal of Cardiology·M B RosenbaumM V Elizari
Aug 1, 1975·British Heart Journal·D A PritchardP J Hurley
Aug 1, 1974·The American Journal of Cardiology·M B RosenbaumM V Elizari
Apr 1, 1980·Journal of Electrocardiology·D E WardR A Spurrell
Jan 1, 1982·Pharmacology & Therapeutics·R S Bexton, A J Camm
Mar 1, 1981·European Journal of Clinical Pharmacology·F AndreasenH Gøtzsche
Dec 1, 1981·Journal of Pharmaceutical Sciences·L J LeskoC Haffajee
Jan 18, 1980·Journal of Chromatography·R J FlanaganD W Holt
Citations
Feb 15, 1985·Klinische Wochenschrift·M Stäubli, H Studer
Sep 1, 1983·Biochemical Pharmacology·P NokinP Schoenfeld
Jun 23, 1992·Biochemical Pharmacology·A M SautereauN Paillous
Jun 19, 1987·European Journal of Pharmacology·P NokinK Schwartz
Apr 1, 1996·Journal of the American College of Cardiology·E GalveJ Soler-Soler
Jul 1, 1986·Journal of the American College of Cardiology·E BarbieriR Latini
Mar 1, 1984·British Heart Journal·N M DebbasP Puech
May 1, 1987·British Heart Journal·J G ClelandJ T Wilson
Nov 26, 1993·The American Journal of Cardiology·D M Roden
Jan 1, 1991·American Heart Journal·S H HohnloserH Just
Aug 30, 1994·Biochemical Pharmacology·N Paillous, S Fery-Forgues
Mar 15, 2015·Biopharmaceutics & Drug Disposition·Zofia Tylutki, Sebastian Polak
Jun 1, 1985·British Journal of Haematology·J F DelfraissyJ Dormont
Jun 11, 2019·Journal of Clinical Apheresis·Anand PadmanabhanGuest Editor Joseph Schwartz
Jul 13, 2019·Journal of the American Veterinary Medical Association·Roy MadiganAlberto E Paniz-Mondolfi
May 1, 1984·British Journal of Pharmacology·B J Northover
Sep 15, 1986·Biochemical Pharmacology·P ChatelainJ M Ruysschaert
Jul 1, 1985·Journal of Pharmaceutical Sciences·P Chatelain, R Laruel