Determination of ceftiofur and its desfuroylceftiofur-related metabolites in swine tissues by high-performance liquid chromatography

Journal of Chromatography. B, Biomedical Applications
M G Beconi-BarkerT J Gilbertson

Abstract

An HPLC method was developed and validated for the determination of ceftiofur-related metabolites that have the potential to be microbiologically active in swine muscle, kidney, liver and fat. Its performance was evaluated against incurred-residue swine tissues. This method is based on the cleavage of the disulfide and/or thioester bonds between the metabolites and their conjugate sulfur containing moiety using dithioerythritol to yield desfuroylceftiofur, and further stabilization to desfuroylceftiofur acetamide. The limit of quantitation was 0.1 micrograms ceftiofur equivalents/g tissue. The assay is specific for ceftiofur-related metabolites when evaluated against commercially available antibiotics for swine.

Citations

Apr 11, 2003·Journal of the American Society for Mass Spectrometry·Clifton K FagerquistAlan G Marshall
Dec 8, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Bjorn J A BerendsenMichel W F Nielen
Dec 17, 2008·The Journal of Antimicrobial Chemotherapy·Angkana TantituvanontDahrit Nilubol
Jun 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·M G Beconi-BarkerS A Brown
Aug 31, 2011·Antimicrobial Agents and Chemotherapy·R Doug WagnerBruce D Erickson
Jun 17, 2004·Journal of the American Veterinary Medical Association·Geof W SmithRonald E Baynes
Jun 18, 2014·Drug Design, Development and Therapy·Cristian VilosLuis A Velasquez
Jul 16, 2014·TheScientificWorldJournal·Agnieszka DołhańMarcelina Bębenek
May 15, 2012·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Shixia FengElizabeth A Tall
Jan 20, 2006·Journal of Veterinary Pharmacology and Therapeutics·G BoschJ M Ensink
Jan 12, 2011·Journal of Veterinary Pharmacology and Therapeutics·S LiuW Zhou
Dec 29, 2016·American Journal of Veterinary Research·Scott H EdwardsSharanne L Raidal
Mar 21, 2017·Journal of Veterinary Pharmacology and Therapeutics·M L MacphersonM M LeBlanc
Nov 2, 2018·The Journal of Veterinary Medical Science·Jincheng XiongYinsheng Qiu
Nov 7, 2007·The Journal of Veterinary Medical Science·Hee Sik ChungHu Jang Lee
Nov 26, 2016·Journal of Veterinary Pharmacology and Therapeutics·J W SparksJ F Coetzee
Aug 6, 1998·Journal of Chromatography. a·R W Fedeniuk, P J Shand
Jul 15, 2000·Journal of Chromatography. a·L K Sørensen, L K Snor
May 16, 2021·Veterinary Medicine and Science·Tara N GaireVictoriya V Volkova
Nov 21, 2007·Journal of Agricultural and Food Chemistry·Xiaoguang ZhangJianzhong Shen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.