PMID: 11924712Apr 2, 2002Paper

Determination of chronic abuse of the anaesthetic agents midazolam and propofol as demonstrated by hair analysis

International Journal of Legal Medicine
V CirimeleB Ludes

Abstract

A 44-year-old female nurse in a department of anesthesiology was found dead at home. An empty bottle of Hypnovel (midazolam 5 mg/5 ml) and a hypodermic syringe were found near the corpse. The nurse was a known abuser of anaesthetic agents for many years. A complete screening for general unknown substances by FPIA, GC/MS, head space GC/MS and HPLC/DAD revealed the simultaneous presence of midazolam, propofol and ethanol in femoral blood. Segmental analysis of a 6-cm-long hair strand revealed the presence of midazolam and propofol in each 2-cm-long segment. Repetitive consumption of the two anaesthetic agents during the last 6 months before the death was therefore demonstrated. These compounds were also detected in pubic and axillary hairs. Self-administration of midazolam and propofol without respiratory assistance and medical control certainly contributed to the death.

Citations

May 9, 2007·Analytical and Bioanalytical Chemistry·Frank Musshoff, Burkhard Madea
Jun 19, 2013·Analytical and Bioanalytical Chemistry·Jihyun KimSooyeun Lee
Jul 6, 2006·International Journal of Legal Medicine·S SeidlP Betz
Aug 29, 2012·Forensic Science, Medicine, and Pathology·Takahito HayashiMichael Tsokos
May 24, 2006·International Journal of Toxicology·Vassiliki A BoumbaTheodore Vougiouklakis
Dec 17, 2009·Clinical Nurse Specialist CNS·Patricia O'Malley
Apr 8, 2006·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Marie Balíková
Jul 13, 2004·International Journal of Legal Medicine·Fabio De GiorgioMarcello Chiarotti
Apr 6, 2011·Substance Use & Misuse·Todd MonroeRonald Cowan
Jun 12, 2009·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Irene RiezzoVittorio Fineschi
Oct 30, 2015·The American Journal of Forensic Medicine and Pathology·Alan A GeorgeD Kimberley Molina
Apr 29, 2016·Journal of Forensic Sciences·Yi YeLinchuan Liao
May 12, 2010·Journal of Emergency Nursing : JEN : Official Publication of the Emergency Department Nurses Association·Nicki Gilboy
Sep 18, 2007·Fundamental & Clinical Pharmacology·Anne RoussinMaryse Lapeyre-Mestre
May 29, 2008·Biomedical Chromatography : BMC·E Gallardo, J A Queiroz
Oct 19, 2010·Journal of Forensic Sciences·Richard J Levy
Jun 3, 2004·Forensic Science International : Synergy·Olaf H Drummer
Apr 21, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Fritz Pragst, Marie A Balikova
Jan 25, 2006·Forensic Science International : Synergy·Elena F KraniotiManolis Michalodimitrakis
Mar 30, 2017·International Journal of Dermatology·Francesco RicciKetty Peris
Jan 15, 2014·Analytical and Bioanalytical Chemistry·Fabio VaianoElisabetta Bertol
Mar 21, 2009·Anesthesia and Analgesia·Robert R KirbyMichael M Douglas
Jul 27, 2021·Forensic Science International : Synergy·Sara GwiazdaLinda M Mulligan
Sep 30, 2021·Journal of Forensic Sciences·Guillaume DrevinChadi Abbara

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