PMID: 8458896Mar 5, 1993Paper

Determination of clozapine and desmethylclozapine in human plasma by high-performance liquid chromatography with ultraviolet detection

Journal of Chromatography
M C ChungM W Jann

Abstract

A method using reversed-phase high-performance liquid chromatography for the simultaneous determination of clozapine and its desmethyl metabolite in human plasma has been established. Clozapine and N-desmethylclozapine were extracted with n-hexane-isoamyl alcohol (98.5:1.5, v/v). Protriptyline served as the internal standard. The limits of detection for clozapine and desmethylclozapine are 2 and 1 ng/ml, respectively. The sensitivity and precision of this method can be utilized for pharmacokinetic studies and therapeutic drug monitoring regimens.

Citations

Jan 1, 1996·The Psychiatric Quarterly·T B Cooper
Sep 2, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·W H ChangM W Jann
Jun 8, 2001·Journal of Chromatography. B, Biomedical Sciences and Applications·A LlerenaA de la Rubia
Apr 18, 1997·Forensic Science International : Synergy·T KellerR Dirnhofer
Jan 7, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·B Buur-Rasmussen, K Brøsen
Mar 18, 2008·Biomedical Chromatography : BMC·Guodong ZhangMichael G Bartlett
Aug 26, 1998·The Australian and New Zealand Journal of Psychiatry·R BellD Copolov
Sep 5, 2001·The Australian and New Zealand Journal of Psychiatry·R BellD Copolov
Jul 6, 2011·European Journal of Oral Sciences·Tania GodoyJörgen Ekström
Oct 12, 2014·Psychiatric Genetics·Veeramanikandan RajagopalMolly Jacob
Nov 28, 2002·Journal of Clinical Psychopharmacology·Mong-Liang LuWen-Ho Chang
Aug 1, 1997·Therapeutic Drug Monitoring·H WeigmannC Hiemke

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