Determination of Common Antipsychotics in Quantisal-Collected Oral Fluid by UHPLC-MS/MS: Method Validation and Applicability for Therapeutic Drug Monitoring

Therapeutic Drug Monitoring
Lisbeth PatteetHugo Neels

Abstract

Oral fluid (OF) is an interesting alternative for conventional blood testing in therapeutic drug monitoring. OF can be used for screening but its value for quantification has to be established. To evaluate the value of OF for quantification of 11 commonly used antipsychotics (APs) and 5 metabolites, an ultra-high performance liquid chromatography-tandem mass spectrometric method was validated. OF was obtained from psychiatric patients using a Quantisal collection device. OF to serum concentration ratios were determined, taking into account the exact volume of collected OF. Linearity was evaluated at 7 or 8 calibration levels. Accuracy criteria were fulfilled, except for pipamperone (PIP) at quality control (QC) low. The intraday precision ranged 0.88%-14.73% and interday precision ranged 1.92%-16.17%. The mean recovery from the collection pad was 37.1% at QC low and 40.3% at QC high for 1 mL of collected OF; for 0.5 mL collected OF mean recovery was 35.0% at QC low and 37.3% at QC high. When 0.1 mL OF was collected, recovery data were unreliable. Mean absolute matrix effect was 101.1% (82.0%-120.0%). OF patient samples (n = 89) containing 269 APs and metabolites were acquired and the mean volume of collected OF was 0.562 mL (0....Continue Reading

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Citations

May 11, 2016·Clinical Biochemistry·Maria Shipkova, Dobrin Svinarov
Jul 12, 2019·Analytical and Bioanalytical Chemistry·Débora CarameloEugenia Gallardo
Aug 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ewelina Dziurkowska, Marek Wesolowski
Sep 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomasz Tuzimski, Anna Petruczynik
Mar 13, 2018·Therapeutic Drug Monitoring·Jasna NeumannMichael Böttcher
Jan 7, 2020·Mass Spectrometry Reviews·Jia-Jia CuiJi-Ye Yin
Dec 13, 2019·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ewelina DziurkowskaMarek Wesolowski

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