PMID: 2493082Feb 1, 1989Paper

Determination of degree of energy restriction necessary to reduce DMBA-induced mammary tumorigenesis in rats during the promotion phase

The Journal of Nutrition
D M KlurfeldD Kritchevsky

Abstract

This study was designed to determine the degree of energy restriction necessary to achieve significant inhibition of mammary tumor promotion in rats treated with 7,12-dimethylbenz[a]anthracene (DMBA). A control group of rats was fed a diet containing 5% corn oil ad libitum. Four other groups were pair-fed to the controls; these rats were subjected to energy restriction of 10, 20, 30, or 40%. Weight gains among the groups were proportional to energy intake. The differences in weight were due primarily to reductions in body fat stores. Tumor incidence was reduced slightly by 20% calorie restriction and significantly by 30 and 40% restriction. There were also reductions in number of tumors per tumor-bearing rat and in mean tumor weight. The groups subjected to 30 and 40% energy restriction had significantly reduced serum levels of insulin in the fasting state. These data suggest that body weight, body fat, and fasting serum insulin correlate with susceptibility to mammary tumor promotion and that insulin may be a growth factor for DMBA-induced tumors.

Citations

Jan 1, 1992·Nutrition and Cancer·L D Youngman, T C Campbell
May 15, 1989·International Journal of Cancer. Journal International Du Cancer·D M KlurfeldD Kritchevsky
Jul 3, 1998·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·K P KeenanR Dixit
Mar 28, 1998·Breast Cancer Research and Treatment·D Kritchevsky
Nov 8, 2002·The Journal of Nutrition·Elizabeth A Platz
Jun 19, 2007·Nutrition and Cancer·David M Klurfeld, Jon A Story
Mar 13, 2009·Nature·Nada Y Kalaany, David M Sabatini
Jun 13, 2012·Journal of Cellular Physiology·Anna RossiniAndrea Balsari
Sep 15, 1990·Cancer·D Kritchevsky
Feb 1, 1993·The Proceedings of the Nutrition Society·D Kritchevsky
Dec 7, 2002·Nutrition and Cancer·Cristina Rodríguez-BurfordClinton J Grubbs
May 2, 2002·The Journal of Nutrition·Henry J ThompsonWeiqin Jiang
Dec 2, 2005·Breast Cancer Research and Treatment·Stephanie A Navarro SilveraThomas E Rohan
Mar 15, 2012·The Proceedings of the Nutrition Society·Michelle Harvie, Anthony Howell
Mar 16, 2005·Experimental Lung Research·Chung S YangGary Lu
Aug 30, 2000·Human & Experimental Toxicology·K P Keenan
May 29, 2002·Hybridoma and Hybridomics·David Kritchevsky
Sep 28, 2013·Essays in Biochemistry·G Vignir HelgasonKevin M Ryan
Nov 11, 2003·The Journal of Nutrition·David Kritchevsky
Jul 25, 2007·The Journal of Biological Chemistry·Linglin XieWeiqun Wang
Jan 20, 2006·Journal of Biochemical and Molecular Toxicology·Liang LiJeanette C Roberts

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