Determination of dependencies among in vitro and in vivo properties of prepared mucoadhesive buccal films using multivariate data analysis

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
David VetchýJan Stembírek

Abstract

Mucoadhesive films represent the most developed medical form of buccal application. Despite the intense focus on buccal film-based systems, there are no standardized methods for their evaluation, which limits the possibility of comparison of obtained data and evaluation of the significance of influence of formulation and process variables on properties of resulting films. The used principal component analysis, together with a partial least squares regression provided a unique insight into the effects of in vitro parameters of mucoadhesive buccal films on their in vivo properties and into interdependencies among the studied variables. In the present study eight various mucoadhesive buccal films based on mucoadhesive polymers (carmellose, polyethylene oxide) were prepared using a solvent casting method or a method of impregnation, respectively. An ethylcellulose or hydrophobic blend of white beeswax and white petrolatum were used as a backing layer. The addition of polyethylene oxide prolonged the in vivo film residence time (from 53.24±5.38-74.18±5.13 min to 71.05±3.15-98.12±1.75 min), and even more when combined with an ethylcellulose backing layer (98.12±1.75 min) and also improved the film's appearance. Tested non-woven texti...Continue Reading

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Citations

Jan 18, 2016·Colloids and Surfaces. B, Biointerfaces·Yan JiaoGuangxi Zhai
Jun 20, 2015·BioMed Research International·Lenka VinklárkováJurga Bernatonienė
Jun 14, 2016·Pharmaceutical Development and Technology·Veronika WalicováDavid Vetchý
Feb 16, 2017·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Zdeněk DaněkJan Štembírek
Mar 10, 2017·Drug Development and Industrial Pharmacy·Jéssica Bassi da SilvaMarcos Luciano Bruschi
Aug 7, 2019·Expert Opinion on Drug Delivery·Yu TianJ Carolina Visser
Jan 17, 2020·Drug Development and Industrial Pharmacy·Annibal TorregrosaEduardo Savio
Apr 11, 2019·Polymers·Jéssica Bassi da SilvaMarcos Luciano Bruschi

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