PMID: 11604273Oct 18, 2001Paper

Determination of dexamethasone and two excipients (creatinine and propylparaben) in injections by using UV-spectroscopy and multivariate calibrations

International Journal of Pharmaceutics
María S ColladoH C Goicoechea

Abstract

The use of multivariate spectrophotometric calibration for the simultaneous determination of dexamethasone and two typical excipients (creatinine and propylparaben) in injections is presented. The resolution of the three-component mixture in a matrix of excipients has been accomplished by using partial least-squares (PLS-1). Notwithstanding the elevated degree of spectral overlap, they have been rapidly and simultaneously determined with high accuracy and precision (comparable to the HPLC pharmacopeial method), with no interference, and without resorting to extraction procedures using non-aqueous solvents. A simple and fast method for wavelength selection in the calibration step is used, based on the minimisation of the predicted error sum of squares (PRESS) calculated as a function of a moving spectral window.

References

Mar 7, 2000·Journal of Pharmaceutical and Biomedical Analysis·H C Goicoechea, A C Olivieri
Oct 31, 2008·Talanta·A G GonzálezA G Asuero

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Citations

Nov 23, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Hayam M LotfyMostafa A Shehata
Feb 17, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zheng ZhangJan Feijen
Mar 14, 2019·Journal of Analytical Methods in Chemistry·Hayam M Lotfy, Sarah S Saleh
Apr 1, 2019·Journal of Chromatographic Science·Shereen Mostafa TawakkolMostafa Abdel-Atty Shehata
Aug 30, 2003·Analytical Chemistry·R K Gilpin, L A Pachla

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