PMID: 9187404Apr 25, 1997Paper

Determination of dexamethasone in tears by capillary electrophoresis

Journal of Chromatography. B, Biomedical Sciences and Applications
V BaeyensR Gurny

Abstract

A selective capillary zone electrophoresis (CZE) microassay was developed for the simultaneous determination of dexamethasone phosphate and its major metabolite, dexamethasone, in tears. The calibration was carried out in the biological matrix with indoprofen as an internal standard which allowed the separation of dexamethasone phosphate and dexamethasone from the tear constituents. The limits of detection and quantification of the assay were 0.5 and 2.0 microg ml(-1), respectively. This quantification method is essential for the in vivo determination of dexamethasone concentration-time profiles in tears after application of the antiinflammatory drug.

Citations

Feb 10, 1998·Electrophoresis·F von Heeren, W Thormann
Mar 17, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Valerie A Frerichs, Kathleen M Tornatore
Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·V BaeyensR Gurny
Nov 1, 2002·Journal of Pharmaceutical and Biomedical Analysis·J M Lemus Gallego, J Pérez Arroyo
Aug 30, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M ZignaniR Gurny
Nov 23, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Hayam M LotfyMostafa A Shehata
Apr 22, 2008·Journal of Pharmaceutical Sciences·E VegaM A Egea
Aug 4, 2006·Journal of Pharmaceutical Sciences·E VegaM L García
May 4, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·F LallemandR Gurny
Mar 14, 2019·Journal of Analytical Methods in Chemistry·Hayam M Lotfy, Sarah S Saleh
Apr 1, 2019·Journal of Chromatographic Science·Shereen Mostafa TawakkolMostafa Abdel-Atty Shehata
Jun 17, 1999·Annals of Clinical Biochemistry·D Perrett

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