Determination of dimethoate in blood and hemoperfusion cartridge following ingestion of formothion: a case study

Forensic Science International : Synergy
T KojimaT Miyazaki

Abstract

A 57-year-old male who had ingested not more than 22 g of formothion was semicomatose on admission to hospital, approximately 1.5 h after ingestion. Dimethoate, a hydrolyzed formothion, was found in blood samples collected from the patient and in the charcoal column in the direct hemoperfusion cartridge which was used 6 to 7.5 h after ingestion. It was extracted and purified by Extrelut column extraction. A gas chromatograph, equipped with a flame photometric detector and a gas chromatograph-mass spectrometer, were used to detect and confirm the presence of dimethoate. The blood dimethoate concentrations which were taken approximately 1.5 and 6 h after ingestion were 21.4 and 12.7 micrograms/g, respectively. A blood dimethoate concentration of 21.4 micrograms/g would appear to indicate a high level of formothion intoxication. The total amount of dimethoate found in the charcoal column used was 15 mg.

Citations

Feb 14, 2006·Rapid Communications in Mass Spectrometry : RCM·E GallardoM López-Rivadulla
Jun 7, 2015·Journal of Forensic and Legal Medicine·Nuno I P ValenteHelena M Teixeira
Jun 5, 2010·Biological & Pharmaceutical Bulletin·Kazuo NakamotoShogo Tokuyama
Mar 19, 2002·Therapeutic Drug Monitoring·Ralf RegenthalRainer Preiss

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