Determination of endocrine-disrupting compounds in drinking waters by fast liquid chromatography-tandem mass spectrometry

Journal of Mass Spectrometry : JMS
Emanuele MagiCamilla Liscio

Abstract

Growing attention has been recently paid to safety of food and drinking water, making necessary the adoption of policies for water sources protection and the development of sensitive and rapid analytical methods to identify micropollutants. Endocrine-disrupting compounds (EDCs) have emerged as a major issue as they alter the functioning of the endocrine system. Since ingestion of EDCs via food is considered the major exposure route, there is a growing interest in understanding EDC fate during drinking water treatment and in monitoring potential contamination of surface waters and groundwaters. In this work, a fast liquid chromatography-electrospray ionization-tandem mass spectrometry method was developed for the determination of 4-n-nonylphenol (NP), bisphenol A (BPA), estrone (E1), 17β-estradiol (E2) and 17α-ethinylestradiol (EE2) in drinking waters. In the literature analytical articles seldom provide details regarding fragmentation pathways. In this paper spectra of the five EDCs in negative ESI were interpreted with the support of accurate mass spectra acquired by a quadrupole time-of-flight instrument; fragmentation pathways were also proposed. The chromatographic separation of EDCs was optimized on a Pinnacle DB Biphenyli...Continue Reading

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Citations

Mar 8, 2013·Ecotoxicology and Environmental Safety·Qiang ZengWen-Qing Lu
Mar 10, 2016·Journal of the American Society for Mass Spectrometry·Evelyn H WangKevin A Schug
Nov 15, 2014·Journal of Mass Spectrometry : JMS·Emanuele Magi, Shivani Tanwar
Jul 25, 2018·Environmental Science and Pollution Research International·Harpreet KaurGulshan Bansal
Jun 18, 2019·Critical Reviews in Analytical Chemistry·Klaudia GodlewskaMonika Paszkiewicz

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