Determination of glycosylated haemoglobins with the "fast haemoglobin test system": methodological aspects (author's transl)

Deutsche medizinische Wochenschrift
P Schauder, W Hintz

Abstract

Tenfold determination of HbA1a+b+c from ten different blood samples by means of the "fast haemoglobin test system":" gave a standard deviation of 0.12% for the same sample. Serial observations on the same group of subjects without metabolic abnormalities indicated differing quality of various samples in the test system. Measurements on capillary blood, venous blood and heparinised blood gave identical values. Blood or haemolysate could be stored for at least three days at 22.5 degrees C, 4 degrees C or -20 degrees C, column eluate at 22.5 degrees C for at least five hours without altering the results. Hyperlipaemic blood led to the obtaining of falsely high values and had to be washed before analysis. Acute elevation in blood-glucose level induced by an oral glucose tolerance test of maturity-onset diabetics requiring insulin led to a short-lived rise in HbA1a+b+c. The "fast haemoglobin test system" is, after elimination of certain potential errors, a simple, rapid and reproducible means of measuring HbA1a+b+c. The concentration of HbA1a+b+c apparently mirrors shortlived changes in blood sugar level and not only longterm effects on the metabolic state.

Citations

Feb 20, 1982·British Medical Journal·F Goebel, H Fuessl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.