Determination of glyphosate in biological fluids by 1H and 31P NMR spectroscopy

Forensic Science International : Synergy
B CartignyM Lhermitte

Abstract

Identification of glyphosate in four cases of poisoning, using nuclear magnetic resonance spectroscopy of biological fluids is reported. It has been performed by using a combination of 1H and 31P NMR analyses. Characterization of the N-(phosphonomethyl) glycine herbicide was achieved by chemical shift considerations and coupling constant patterns: CH2-(P) presents specific resonance at 3.12 ppm and appears as a doublet with a H-P characteristic coupling constant of 12.3 Hz. Moreover, resonances due to isopropylamine were present, confirming the ingestion of the considered trade formulation. After a calibration step, quantitation was performed by 1H and 31P NMR spectroscopy. The benefit and reliability of NMR investigations of biological fluids are discussed, particularly when the clinical picture is quite confusing.

References

Jan 1, 1991·Human & Experimental Toxicology·A R TalbotT R Sanford
Sep 1, 1988·Journal of Analytical Toxicology·S J DicksonT D Koelmeyer
Jan 11, 2000·Human & Experimental Toxicology·F W Sorensen, M Gregersen
Aug 25, 2000·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·H L LeeL M Tsai
May 14, 2003·Forensic Science International : Synergy·M ImbenotteM Lhermitte

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Citations

May 18, 2012·Environmental Science & Technology·Pierluigi Mazzei, Alessandro Piccolo
Feb 2, 2016·Forensic Science International : Synergy·Joseph HanHeesun Chung
Jan 8, 2013·Forensic Science International : Synergy·K ZouaouiG Lachâtre
Apr 3, 2018·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Maiko TaharaHideto Jinno
Oct 17, 2018·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Pâmela C OliveiraGilberto J Arruda
Apr 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elena ShumilinaAlexander Dikiy
Aug 14, 2019·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Piotr Rychter
Jun 15, 2005·Analytical Chemistry·T A BrettellR Saferstein

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