Determination of HLA-A, -C, -B, -DRB1 allele and haplotype frequency in Japanese population based on family study

Tissue Antigens
N IkedaH Saji

Abstract

The present study investigates the human leucocyte antigen (HLA) allele and haplotype frequencies in Japanese population. We carried out the frequency analysis in 5824 families living across Japanese archipelago. The studied population has mainly been typed for the purpose of transplant, especially the hematopoietic stem cell transplantation (HSCT). We determined HLA class I (A, B, and C) and HLA class II (DRB1) using Luminex technology. The haplotypes were directly counted by segregation. A total of 44 HLA-A, 29 HLA-C, 75 HLA-B, and 42 HLA-DRB1 alleles were identified. In the HLA haplotypes of A-C-B-DRB1 and C-B, the pattern of linkage disequilibrium peculiar to Japanese population has been confirmed. Moreover, the haplotype frequencies based on family study was compared with the frequencies estimated by maximum likelihood estimation (MLE), and the equivalent results were obtained. The allele and haplotype frequencies obtained in this study could be useful for anthropology, transplantation therapy, and disease association studies.

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Citations

Feb 24, 2016·HLA : Immune Response Genetics·S SuzukiT Shiina
Jul 24, 2015·Journal of Human Genetics·Hirofumi Nakaoka, Ituro Inoue
Nov 21, 2015·Human Immunology·Eduardo Jose Melos Dos SantosDerek Middleton
Jun 15, 2016·Modern Rheumatology·Toshitaka KizawaHiroyuki Tsutsumi
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Feb 17, 2019·The Journal of Rheumatology·Mitsumasa KishimotoTetsuya Tomita
Jan 17, 2020·International Journal of Rheumatic Diseases·Worawit LouthrenooFujio Takeuchi
Aug 24, 2018·Modern Rheumatology·Yuya FujitaKiyoshi Migita
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Dec 1, 2020·Thrombosis and Haemostasis·Keiko ShinozawaUNKNOWN study group on JAPAN HEMOPHILIA INHIBITOR STUDY (J-HIS)

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Software Mentioned

haplo
Excel
mle
HLA Fusion
stats
wakflow Typing
R
genepop
em

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