PMID: 11227574Mar 3, 2001Paper

Determination of idarubicin in human urine by capillary zone electrophoresis with amperometric detection

Fresenius' Journal of Analytical Chemistry
Q HuY Fang


A simple, reliable and reproducible method, based on capillary zone electrophoresis with amperometric detection, has been developed for the determination of idarubicin in human urine. A carbon disk electrode was used as working electrode. The optimal conditions of separation and detection were pH 5.6 phosphate buffer (0.20 mol/L), 22 kV for the separation voltage and 1.00 V (vs. Ag/AgCl, 3 mol/L KCl) for the detection potential. The linear range was from 4.0 x 10(-7) to 2.0 x 10(-5) mol/L with a regression coefficient of 0.9986, and the detection limit was 8.0 x 10(-8) mol/L. The method was directly applied to the determination of idarubicin in spiked human urine without any other sample pretreatment except filtration, and the assay results were satisfactory.


Feb 19, 2004·Archives of Pharmacal Research·Younghee Hahn, Ho Young Lee
Nov 13, 2015·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Julius Mbuna, Takashi Kaneta

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