Determination of ideal offset for spatially offset Raman spectroscopy

Applied Spectroscopy
Jason R Maher, Andrew J Berger

Abstract

A key design parameter in spatially offset Raman spectroscopy (SORS) is the choice of offset distance between the illumination and collection areas. To investigate this choice, we performed SORS measurements on a simple two-layer chemical phantom. We show that while the SORS ratio, or the ratio of signal from the bottom layer to the top layer, monotonically increases with spatial offset, the signal-to-noise ratio (SNR) does not. Specifically, we show that there exists a specific spatial offset that yields the best SNR for signal originating in the bottom layer of a two-layer sample. We also show that this SNR-optimal offset depends upon the strength of the particular Raman band. This work presents the considerations that should be taken into account when designing optical probes for use in SORS.

References

Dec 9, 2003·Applied Spectroscopy·Chad A Lieber, Anita Mahadevan-Jansen
Jul 21, 2006·Applied Spectroscopy·Pavel MatousekAnthony W Parker
Jan 11, 2007·Journal of Biomedical Optics·Matthew V SchulmerichSteven A Goldstein
Apr 3, 2009·Optics Letters·Matthew D KellerAnita Mahadevan-Jansen

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Citations

Jan 30, 2014·Bioanalysis·Janusz M SmulkoIshan Barman
Oct 13, 2015·Chemical Society Reviews·Pavel Matousek, Nicholas Stone
Jul 8, 2017·Sensors·Nandan K DasZachary J Smith
Dec 3, 2010·The Analyst·Kevin Buckley, Pavel Matousek
Oct 2, 2020·Analytical Methods : Advancing Methods and Applications·Holly FlemingKishan Dholakia
Sep 5, 2020·Biomedical Engineering and Computational Biology·Martha Z Vardaki, Nikolaos Kourkoumelis
Nov 7, 2012·Journal of Biophotonics·Pavel Matousek, Nicholas Stone
Jun 30, 2018·Journal of Biomedical Optics·Eliana CorderoJürgen Popp
Nov 11, 2020·Chemical Society Reviews·Fay NicolsonPavel Matousek

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