Determination of Imazaquin and its metabolite by liquid chromatography-quadrupole-time of flight tandem mass

Bulletin of Environmental Contamination and Toxicology
H B YaoC H Wang

Abstract

A method consisting of solvent extraction followed by liquid chromatography-quadrupole-time of flight- tandem mass spectrometry analysis was developed for the identification of Imazaquin and its metabolite. The relationships between detector response and sample concentrations showed a high degree of linearity (r > 0.998) over the range 0.03-10 microg/g. The recoveries obtained were in the acceptable range of 86%-104% between spiked. The relative standard deviation of this method was 6.4%-17.1%. A 35-day study of Imazaquin degradation was taken in agricultural soil from Binzhou, China. The degradation followed first order kinetics (C = 0.7672e(-0.0774t)), with half-life of less than 8.5 days. Investigation of the by-products from liquid chromatography-quadrupole-time of flight- tandem mass spectrometry has shown that there were four important metabolites 4-methylene-2-(quinolin-2-yl)-1H-imidazol-5(4H)-one, quinoline-3-carbaldehyde, 1-amino-2,3-dimethyl-1-oxobutan-2-ylium and 1H-[1,2]oxazino[4,5-b]quinolin-1-one in the degradation process. The accurate mass measurements error was 5 ppm in this study. The method was successfully applied to the analysis of imazaquin and its metabolite residues in soil.

References

May 20, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Junko AdachiYasuhiro Ueno
Apr 30, 2005·Analytical Chemistry·Imma FerrerAmadeo R Fernández-Alba
Jun 6, 2006·Mass Spectrometry Reviews·Sílvia Lacorte, Amadeo R Fernandez-Alba
Jan 10, 2008·Bulletin of Environmental Contamination and Toxicology·C GuoJ-Z Li

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