PMID: 8938566Nov 1, 1996Paper

Determination of interferon-alpha-producing capacity in whole blood cultures from patients with various diseases and from healthy persons

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
K UnoT Kishida

Abstract

To assess the clinical value of determination of the interferon (IFN)-producing capacity of patients, IFN production induced by Sendai virus (HVJ) in vitro was measured in cell cultures of whole blood from patients with various diseases. IFN production in patients with lung cancer, myelodysplastic syndromes, noninsulin-dependent diabetes mellitus, pulmonary tuberculosis, and asymptomatic HIV-1 infection was lower than that in healthy persons. Furthermore, periodic measurements of IFN production revealed decreasing IFN producing capacities in patients with lung cancer with progression of the tumor stage. However, increased IFN-producing capacities were observed in patients with tuberculosis after standard therapy. Further experiments showed that the main type of IFN induced in whole blood cultures was IFN-alpha, and decreased IFN production in patients did not result from a decreased number of leukocytes but rather from an impairment of cellular IFN production. The evaluation of IFN production in whole blood cell cultures may be a feasible method of assessing the impaired immune status.

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Citations

Aug 28, 1998·Mechanisms of Ageing and Development·L RinkH Kirchner
Mar 18, 2000·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·W ChehadehD Hober
Jan 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K UnoT Kishida
Jan 11, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Kazuko UnoTsunataro Kishida
Feb 20, 2013·International Journal of Cancer. Journal International Du Cancer·Takeshi IshikawaToshikazu Yoshikawa
Feb 2, 2018·International Journal of Cancer. Journal International Du Cancer·Takeshi IshikawaYoshito Itoh
Jul 1, 2011·Experimental and Therapeutic Medicine·Takeshi IshikawaToshikazu Yoshikawa
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T ItoS Fukuhara

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