PMID: 108368May 1, 1979

Determination of intravenous non-protein energy and nitrogen requirements in growing rats

The Journal of Nutrition
R C TaoA M Wolfe


Two experiments were conducted to estimate total non-protein energy and nitrogen requirements in growing healthy male Wistar rats nourished by parenteral nutrition. In experiment 1, non-protein energy varying from 30 to 70 kcal/day/rat were administered to animals receiving a constant dose of 80 mg nitrogen, plus vitamins and minerals. In experiment 2, nitrogen dosages varying from 0 to 280 mg N/day/rat with a constant dose of 60 kcal non-protein energy were studied. The formulation of the amino acid solution used in both experiments was based upon recommended oral amino acid requirements for growing rats. Dextrose served as the source of non-protein energy. Weight gain and nitrogen balance during a 6-day experimental period were used to determine requirements. Plasma free amino acids were also analyzed to evaluate the amino acid solution. Results indicate that under total parenteral nutrition conditions 578 to 621 mg/kg body weight3/4 nitrogen and 171 to 182 kcal/kg body weight3/4 non-protein energy are required to achieve growth of approximately 3 g/day. Inconsistent responses of plasma amino acid concentrations to the amounts infused were observed. It is suggested that the determined requirements can be applied as guidelines...Continue Reading


Apr 7, 1998·JPEN. Journal of Parenteral and Enteral Nutrition·R D McCauleyJ Hall
Jan 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·F MartinsL Lindmark
Jan 31, 2002·World Journal of Gastroenterology : WJG·Li-Jian LiangJie-Fu Huang
Jan 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K R KritschD M Ney
Jun 15, 2006·The Journal of Toxicological Sciences·Kentaro AsanumaShuichi Chiba
Sep 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·L LindmarkK Lundholm
Feb 25, 2010·Pediatric Surgery International·Hui-Chen LoChien-Hsing Lee
Jun 1, 1996·The American Journal of Physiology·S J EvansT C Welbourne

Related Concepts

Energy Intake
Energy Metabolism
Dietary Requirements
Parenteral Nutrition

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