Determination of ionophores in the tissues of food animals by liquid chromatography

Food Additives and Contaminants
G GerhardtH M Campbell

Abstract

A liquid chromatographic method for determining residues of ionophores in bovine, porcine, and avian tissues is described. Tissues were extracted with iso-octane-ethyl acetate and the extracts purified on silica solid-phase extraction columns. Monensin, narasin and salinomycin were detected by UV absorbance following post-column derivatization with vanillin, and lasalocid was detected underivatized using fluorescence. In muscle, kidney and fat, all drugs were determined from a single sample extract. In liver, a separate extraction was done to determine lasalocid. The detection limit for lasalocid, narasin and salinomycin was 5 ppb; for monensin it was 2 ppb. Average recoveries were: lasalocid-71.0%; monensin-94.3%; salinomycin-97.2%; narasin-94.1%.

Citations

Jan 31, 2002·Food Additives and Contaminants·J A TarbinM Sharman
Feb 3, 2004·Food Additives and Contaminants·M J Scotter, L Castle
Mar 1, 2012·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Soňa TkáčikováMartin Levkut
Jun 5, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·L ClarkeM Danaher
Apr 29, 2006·Food Additives and Contaminants·Mervi Rokka, Kimmo Peltonen
Mar 19, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jing HaJian-Chen Li
Apr 23, 2010·Rapid Communications in Mass Spectrometry : RCM·Susie Y Dai, Timothy J Herrman
Jul 1, 1999·Journal of Dairy Science·J K BernardS A Martin
Aug 6, 1998·Journal of Chromatography. a·R W Fedeniuk, P J Shand
Sep 29, 2009·Journal of Chromatography. a·Brian KinsellaMartin Danaher

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