Determination of Kanamycin by High Performance Liquid Chromatography

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Xingping ZhangHualin Yang

Abstract

Kanamycin is an aminoglycoside antibiotic widely used in treating animal diseases caused by Gram-negative and Gram-positive infections. Kanamycin has a relatively narrow therapeutic index, and can accumulate in the human body through the food chain. The abuse of kanamycin can have serious side-effects. Therefore, it was necessary to develop a sensitive and selective analysis method to detect kanamycin residue in food to ensure public health. There are many analytical methods to determine kanamycin concentration, among which high performance liquid chromatography (HPLC) is a common and practical tool. This paper presents a review of the application of HPLC analysis of kanamycin in different sample matrices. The different detectors coupled with HPLC, including Ultraviolet (UV)/Fluorescence, Evaporative Light Scattering Detector (ELSD)/Pulsed Electrochemical Detection (PED), and Mass Spectrometry, are discussed. Meanwhile, the strengths and weaknesses of each method are compared. The pre-treatment methods of food samples, including protein precipitation, liquid-liquid extraction (LLE), and solid-phase extraction (SPE) are also summarized in this paper.

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Citations

Nov 25, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Davi de Lacerda CoriolanoIsabella Macário Ferro Cavalcanti
Oct 22, 2020·Biomedical Chromatography : BMC·Victor DavidToma Galaon

Methods Mentioned

BETA
Light Scattering
reverse phase liquid chromatography

Related Concepts

Metazoa
Bacteriocidal Agents
High Pressure Liquid Chromatography Procedure
Food Analysis
Chemical Fractionation
Kantrex
Food Web
Antibiotics, Aminoglycoside
Liquid Chromatography
Food

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

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