Determination of key diffusion and partition parameters and their use in migration modelling of benzophenone from low-density polyethylene (LDPE) into different foodstuffs

Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Joaquim MaiaPerfecto Paseiro

Abstract

The mass transport process (migration) of a model substance, benzophenone (BZP), from LDPE into selected foodstuffs at three temperatures was studied. A mathematical model based on Fick's Second Law of Diffusion was used to simulate the migration process and a good correlation between experimental and predicted values was found. The acquired results contribute to a better understanding of this phenomenon and the parameters so-derived were incorporated into the migration module of the recently launched FACET tool (Flavourings, Additives and Food Contact Materials Exposure Tool). The migration tests were carried out at different time-temperature conditions, and BZP was extracted from LDPE and analysed by HPLC-DAD. With all data, the parameters for migration modelling (diffusion and partition coefficients) were calculated. Results showed that the diffusion coefficients (within both the polymer and the foodstuff) are greatly affected by the temperature and food's physical state, whereas the partition coefficient was affected significantly only by food characteristics, particularly fat content.

References

Jul 1, 1997·Food Additives and Contaminants·M HamdaniJ M Vergnaud
Jul 27, 2001·Food Additives and Contaminants·P Hernandez-MuñozR Gavara
Feb 1, 2002·Food Additives and Contaminants·I E HelmrothT Hankemeier
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Apr 1, 2005·Food Additives and Contaminants·E A Tehrany, S Desobry
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Nov 13, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·P K T OldringL Castle

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Citations

Oct 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Miguel A LagoAna Rodríguez-Bernaldo de Quirós
Dec 24, 2017·Archives of Toxicology·Peter LauxAndreas Luch

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Software Mentioned

FACET
2AD
- 2AD
HP ChemStation
DiffSim
DifSim

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