Determination of kinetic parameters of 1,3-propanediol fermentation by Clostridium diolis using statistically optimized medium

Bioprocess and Biosystems Engineering
Guneet KaurSubhash Chand

Abstract

1,3-propanediol (1,3-PD) is a chemical compound of immense importance primarily used as a raw material for fiber and textile industry. It can be produced by the fermentation of glycerol available abundantly as a by-product from the biodiesel plant. The present study was aimed at determination of key kinetic parameters of 1,3-PD fermentation by Clostridium diolis. Initial experiments on microbial growth inhibition were followed by optimization of nutrient medium recipe by statistical means. Batch kinetic data from studies in bioreactor using optimum concentration of variables obtained from statistical medium design was used for estimation of kinetic parameters of 1,3-PD production. Direct use of raw glycerol from biodiesel plant without any pre-treatment for 1,3-PD production using this strain investigated for the first time in this work gave results comparable to commercial glycerol. The parameter values obtained in this study would be used to develop a mathematical model for 1,3-PD to be used as a guide for designing various reactor operating strategies for further improving 1,3-PD production. An outline of protocol for model development has been discussed in the present work.

References

May 23, 2002·Applied Biochemistry and Biotechnology·He HuangGeorge T Tsao
Sep 21, 2004·Journal of Industrial Microbiology & Biotechnology·M González-PajueloI Vasconcelos
Apr 7, 2010·Biotechnology Advances·E Celińska

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Citations

May 12, 2012·Applied Biochemistry and Biotechnology·Guneet KaurSubhash Chand
Feb 28, 2014·Bioprocess and Biosystems Engineering·Igor Viana BrandiEliane Macedo Sobrinho
Sep 1, 2018·Bioprocess and Biosystems Engineering·Aline Gomes de Oliveira Paranhos, Edson Luiz Silva

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