Determination of loratadine and pheniramine from human serum by gas chromatography-mass spectrometry

Journal of Chromatography. B, Biomedical Applications
J Martens

Abstract

In this work, a method for the determination of the antihistaminic drugs loratadine and pheniramine from human serum is presented. Serum samples are extracted under basic conditions with hexane-n-amyl alcohol (95:5, v/v), the analytes are reextracted into diluted hydrochloric acid and, after basification, are once again extracted into the organic phase. The samples are measured by GC-MS. The limits o detection of the assay are 0.5 ng/ml for loratadine and 2 ng/ml for pheniramine. The R.S.D.s in the day-to-day precision test for loratadine are 7.0% at 20 ng/ml and 12.4% at 2 ng/ml. for pheniramine, the R.S.D. are 6.4% at 300 ng/ml and 10.2% at 20 ng/ml.

Citations

Oct 14, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ophelia Q P YinMoses S S Chow
Jan 13, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Moazameh Peyrovi, Mohammadreza Hadjmohammadi
May 14, 2016·Rapid Communications in Mass Spectrometry : RCM·Chi-Wei LeeShyi-Jang Shin
Apr 3, 2016·Biomedical Chromatography : BMC·Maria KatselouSotiris Athanaselis
Sep 16, 2003·Journal of Pharmaceutical and Biomedical Analysis·Ghulam A Shabir, Nigel J Forrow

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