Nov 1, 1975

Determination of low cencentrations of the quaternary ammonium compound thiazinamium methylsulphate in plasma and urine

The Journal of Pharmacy and Pharmacology
J G JonkmanN G Orie


A sensitive and selective method for the quantitative determination of the quaternary ammonium antiacetylcholine-compound thiazinamium methylsulphate (Multergan) in plasma and urine is described. The procedure is based on ion pair extraction of the compound with iodide as the counter ion. This is followed by gas chromatography using an alkali flame ionization detector. The detection limit is 2 ng ml-1 with a recovery of 88-0 +/- 6-2% from plasma, 91-4 +/- 4-6% from urine. The described method can also be applied to other quaternary ammonium compounds.

Mentioned in this Paper

ATP8A2 gene
IL17F gene
Other quaternary ammonium compounds in ATC, muscle relaxants, peripherally acting
ATP8A2 wt Allele
Chromatography, Gas-Liquid
Quaternary Ammonium Compounds
Urine - SpecimenType

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