Determination of lowest possible creatinine in living-donor kidney renal transplant recipients based on donor kidney function

Transplantation
Rebecca SberroEric Thervet

Abstract

The objective of this study was to use information from a donor to establish the lowest possible serum creatinine (SCr) of the recipient as a means of identifying early graft dysfunction. We analyzed retrospectively 58 pairs of living donors and recipients. The lowest possible SCr was calculated from four different formulae derived from Cockcroft-Gault formula: Ax(140-recipient age)xrecipient weight/donor GFR (A, women: 1.04, men: 1.23). Donor GFR was represented by the following values (a) mSCrD0: measured pretransplant GFR for both kidneys, (b) mSCrSKD0: single transplanted kidney GFR on day 0, (c) eSCrD0: estimated GFR based on SCr at day 0, or (d) eSCrD30: on day 30. These resulting estimated SCr were tested for correlation coefficient, bias, precision, and accuracy in predicting the lowest observed recipient SCr during the first year posttransplant. The lowest possible SCr was 80+/-22 micromol/L for mSCrD0, 79.1+/-23 micromol/L for mSCrSKD0, 83+/-27 micromol/L for eSCrD0, and 115+/-22 micromol/L for eSCrD30. Mean values for lowest possible SCr correlated significantly with the lowest observed SCr for all four formulae. The eSCrD0 formula showed the best correlation (r=0.47), the smallest positive bias (20.5 micromol/L), th...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Apr 1, 1994·Journal of the American Society of Nephrology : JASN·P M ter WeeA J Donker
Jun 11, 1999·Journal of the American Society of Nephrology : JASN·D Suri, T W Meyer
Jul 5, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jorge A VelosaMark D Stegall
Feb 18, 2003·Transplantation·Fabienne PessioneChristian Hiesse
Sep 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Visnja LezaicLjubica Djukanovic
Oct 20, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Anjali B SaxenaJane C Tan
Nov 26, 2004·Journal of the American Society of Nephrology : JASN·Magali GiralJean Paul Soulillou
Dec 22, 2004·Annals of Internal Medicine·Lesley A Stevens, Andrew S Levey
Jun 7, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lorenz Risch, Andreas R Huber
Jan 26, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E D PoggioP M Hall
Feb 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E D PoggioW Braun
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M RookG J Navis
Sep 28, 2006·Kidney International·A X GargUNKNOWN Donor Nephrectomy Outcomes Research (DONOR) Network
Dec 22, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Carmel M HawleyDavid Nicol
Mar 14, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K SolezJ J Weening
Mar 14, 2007·Transplantation·Naim IssaEmilio D Poggio
May 2, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ahmed ZahranAhmed Shoker
Aug 21, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·João Batista DouvernyRicardo Sesso

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Citations

Jul 15, 2009·Néphrologie & thérapeutique·C Legendre
Jan 29, 2011·Seminars in Immunopathology·Thomas F MuellerValeria Mas
Nov 19, 2008·Nature Clinical Practice. Nephrology·Greg A Knoll
Mar 25, 2014·Transplantation Proceedings·T SrithongkulK Vareesangthip
Feb 23, 2010·Transplantation Proceedings·S AlvarezL Carreaux
May 14, 2021·Transplantation·Turgay Saritas, Rafael Kramann

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