Determination of milk and mammary tissue concentrations of ceftiofur after intramammary and intramuscular therapy

Journal of Dairy Science
W E OwensS C Nickerson

Abstract

Twenty-five Staphylococcus aureus strains isolated from bovine mastitis were tested for their susceptibility to ceftiofur. Zone diameter for 30 micrograms disks averaged 39 mm, and minimum inhibitory concentrations ranged from .5 to 1 microgram/ml. Tissue and milk concentrations were determined from biopsy and quarter milk samples collected from eight cows treated with either intramammary infusion of 100 or 200 mg of ceftiofur, one or two intramuscular injections of 500 mg of ceftiofur, or combination therapy of intramammary infusion coupled with intramuscular injection. Three additional cows received two intramammary infusions of 200 mg of cephapirin at 24-h intervals. Intramuscular injections of ceftiofur resulted in tissue and milk concentrations below detectable limits. Staphylococcus aureus was not eliminated from infected mammary glands by infusion of 100 mg of ceftiofur or by injection of 500 mg of ceftiofur by 48 h after treatment. Combination therapy of 100 mg of ceftiofur infused and 500 mg injected reduced S. aureus numbers in milk and tissue markedly, as did infusion of 200 mg of ceftiofur. Cows receiving intramammary infusion of 200 mg of ceftiofur (two doses at 24-h intervals) had highest concentrations in milk (4...Continue Reading

References

Jul 1, 1989·The British Veterinary Journal·P G Francis
Aug 1, 1984·The Journal of Dairy Research·A J Bramley, F H Dodd

❮ Previous
Next ❯

Citations

Jun 17, 2004·Journal of the American Veterinary Medical Association·Geof W SmithRonald E Baynes
Nov 6, 2002·Journal of Dairy Science·R J ErskineC R Phipps
Apr 22, 2008·Tropical Animal Health and Production·Sabry A El-Khodery, Salama A Osman
Feb 24, 2012·Journal of Veterinary Pharmacology and Therapeutics·J GoutalierL Goby
May 18, 2013·Journal of Veterinary Pharmacology and Therapeutics·L SuojalaS Pyörälä
Jun 18, 2019·Veterinary Record Open·Luc DurelTerence Pellet
Apr 10, 2003·The Veterinary Clinics of North America. Food Animal Practice·Ronald J ErskineFred J DeGraves

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.