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Determination of nanogram amounts of the antiarrhythmic drug Org 6001 in biological fluids and tissues using selected ion monitoring

Biomedical Mass Spectrometry

Nov 1, 1980

J VinkCees J Timmer

PMID: 7225542

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Abstract

An assay method has been developed to determine the free base of Org 6001 (3 alpha-amino-5 alpha-androstan-2 beta-ol-17-one . HCl) in biological samples. The assay procedure consists of protein denaturation, ethyl acetate extraction, derivatization with tert-butyldimethylchlorosilane in...read more

Mentioned in this Paper

Org 6001
Drug or Chemical Tissue Distribution
Androstanols
Microchemistry
Selected Ion Monitoring
Body Fluids
Cardiac Depressants
Chromatography, Gas-Liquid-Mass Spectrometry
TERT gene
Ethyl acetate

Determination of nanogram amounts of the antiarrhythmic drug Org 6001 in biological fluids and tissues using selected ion monitoring

Biomedical Mass Spectrometry

Nov 1, 1980

J VinkCees J Timmer

PMID: 7225542

DOI:

Abstract

An assay method has been developed to determine the free base of Org 6001 (3 alpha-amino-5 alpha-androstan-2 beta-ol-17-one . HCl) in biological samples. The assay procedure consists of protein denaturation, ethyl acetate extraction, derivatization with tert-butyldimethylchlorosilane in...read more

Mentioned in this Paper

Org 6001
Drug or Chemical Tissue Distribution
Androstanols
Microchemistry
Selected Ion Monitoring

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