Determination of nicotine absorption from multiple tobacco products and nicotine gum.

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Helena DigardAudrey Richter

Abstract

Snus is a smokeless tobacco product traditionally used in Scandinavia and available in pouched or loose forms. The objective of this study was to determine nicotine absorption for current pouched and loose snus products in comparison with a cigarette and an over-the-counter nicotine gum. We conducted an open-label, randomized, 6-way, crossover study involving 20 healthy snus and cigarette users. One of 6 products (2 pouched snus, 2 weights of loose snus, a cigarette, and a nicotine gum) was administered at each of 6 visits. Blood samples were taken at intervals over 120 min and sensory perception assessed by questionnaire. For the 4 smokeless tobacco products and the nicotine gum, blood plasma levels of nicotine were ranked according to total nicotine content as follows: loose snus (27.1 mg nicotine) > pouched snus (14.7 mg nicotine) > loose snus (10.8 mg nicotine) = pouched snus (10.7 mg nicotine) > nicotine gum (4.2 mg nicotine). The area under the plasma concentration-time curve (AUC) and maximum plasma concentration (C(max)) of nicotine ranged from 26.9 to 13.1 ng.h/ml and 17.9 to 9.1 ng.h/ml, respectively across all the products. Nicotine was absorbed more rapidly from the cigarette but systemic exposure was within the ran...Continue Reading

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Citations

May 9, 2014·International Journal of Environmental Research and Public Health·I-Chuan LiYu-Chi Chen
Aug 28, 2013·Psychopharmacology·Lynne Dawkins, Olivia Corcoran
Apr 25, 2014·American Journal of Epidemiology·Mina RydellMaria Rosaria Galanti
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Mar 24, 2016·Journal of Community Health·Héctor E AlcaláA Janet Tomiyama
Oct 7, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Patrick PicavetFrank Lüdicke
Dec 24, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Aadil S InamdarValeria C C Marinho
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Methods Mentioned

BETA
genotyping
pregnancy
contraception

Clinical Trials Mentioned

ISRCTN11703777

Software Mentioned

WinNonlin Enterprise

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