Determination of nighttime salivary cortisol during pregnancy: comparison with values in non-pregnancy and Cushing's disease

Pituitary
Ludmilla Malveira Lima LopesMarcello Delano Bronstein

Abstract

Nighttime salivary cortisol (NSC) has been proposed for the diagnosis of Cushing's syndrome during pregnancy. However, reference values for NCS in pregnant women have not been adequately determined. The aim of this study was to determine the reference values of NSC in the three gestational trimesters in order to help distinguish physiological from pathological hypercortisolism during pregnancy. This prospective and retrospective study evaluated 85 pregnant women in whom samples were collected in the first, second and/or third gestational trimester (pregnancy group), 33 non-pregnant women (control group), and 25 non-pregnant women with Cushing's disease (CD group). NSC was measured by enzyme-linked immunosorbent assay. NSC increased progressively during pregnancy, reaching maximum levels on the third trimester (median 2.1-fold increase compared with controls, p < 0.001). Reference values for NSC were determined and the upper limits on each gestational trimester were: first trimester 0.25 µg/dL (6.9 nmol/L), second trimester 0.26 µg/dL (7.2 nmol/L), and third trimester 0.33 µg/dL (9.1 nmol/L). Cutoff values that separated the CD group from the three trimesters in the pregnancy groups were, respectively, 0.255 µg/dL (7.0 nmol/L), ...Continue Reading

References

Jun 1, 1977·The Journal of Clinical Endocrinology and Metabolism·B E Murphy
Sep 1, 1990·The Journal of Clinical Endocrinology and Metabolism·E M ScottG C Lachelin
Feb 15, 1981·American Journal of Obstetrics and Gynecology·W E Nolten, P A Rueckert
Feb 15, 1983·American Journal of Obstetrics and Gynecology·L CousinsS S Yen
Jan 22, 2003·Seminars in Reproductive Medicine·Peter J Trainer
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·G ArnaldiM Boscaro
Feb 12, 2005·The Journal of Clinical Endocrinology and Metabolism·John R LindsayLynnette K Nieman
Apr 14, 2005·Endocrine Reviews·John R Lindsay, Lynnette K Nieman
Nov 3, 2005·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·H TejuraS Avasarala
Dec 14, 2005·Clinical Endocrinology·Hau LiuElisabeth Ryzen
May 16, 2006·Lancet·John Newell-PriceLynnette K Nieman
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Margaret de Castro, Ayrton C Moreira
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Lucio VilarClaudio E Kater
Mar 13, 2008·The Journal of Clinical Endocrinology and Metabolism·Lynnette K NiemanVictor M Montori
May 1, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Ty CarrollJames W Findling
Nov 26, 2009·European Journal of Endocrinology·Z KaracaF Kelestimur
Dec 1, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Xavier BertagnaJérôme Bertherat
Sep 8, 2010·Reviews in Endocrine & Metabolic Disorders·Ty B Carroll, James W Findling
Sep 21, 2010·Neuroendocrinology·Krystallenia I Alexandraki, Ashley B Grossman
Mar 4, 2011·The Journal of Clinical Endocrinology and Metabolism·Caroline JungWarrick J Inder
Mar 16, 2011·Nature Reviews. Endocrinology·Marcello D BronsteinRaquel S Jallad
Feb 19, 2013·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·T Deutschbein, S Petersenn
Jul 16, 2015·Clinical Endocrinology·Urszula AmbroziakTomasz Bednarczuk

❮ Previous
Next ❯

Citations

Mar 11, 2018·European Journal of Endocrinology·Thierry BrueFrederic Castinetti
Nov 16, 2019·Journal of Clinical Medicine·Hiroshi Nishioka, Shozo Yamada
Mar 7, 2020·The Journal of Clinical Endocrinology and Metabolism·Brandon P GalmNicholas A Tritos
Aug 31, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Madhavi ManoharanShabnum Sibtain
Oct 6, 2018·Annals of the Royal College of Surgeons of England·K JollyN Karavitaki
Nov 3, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrew AntolicMaureen Keller-Wood
Jul 28, 2020·Obstetric Medicine·Riccardo Pofi, Jeremy W Tomlinson
Dec 24, 2018·Obstetric Medicine·Stephanie Teasdale, Adam Morton
Mar 29, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Chaitra JairajVeronica O'Keane
May 23, 2020·Yeungnam University Journal of Medicine·Han Byul KimNam Kyung Kim
Mar 25, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Stephan Petersenn
Mar 30, 2021·Pituitary·Kalyani SridharanN S Kubera
Sep 9, 2021·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Aarthi SundararajanSenthilkumar Natesan
Nov 2, 2021·Clinical Endocrinology·Adam Morton, Stephanie Teasdale

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.