Determination of Ophthalmic Drug Proparacaine Using Multi-walled Carbon Nanotube Paste Electrode by Square Wave Stripping Voltammetry

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
Ersin DemirRecai Inam

Abstract

Proparacaine, one of the most common local anesthetics to facilitate diagnosis and treatment of eye diseases, was assayed by square wave voltammetry using a paste electrode prepared with carbon nanotubes. In cyclic voltammetric studies, proparacaine has exhibited a single irreversible anodic peak at around + 900 mV vs. Ag/AgCl in pH 6.0 Britton-Robinson buffer solution. It was suggested that the peak had appeared due to the oxidation of the NH2 group on the proparacaine molecule. Prior to the determination of the proparacaine by square wave stripping voltammetry (SWSV) on the fabricated multi-walled carbon nanotube paste electrode (MWCNTPE), the accumulation potential (Eacc), accumulation time (tacc), pulse amplitude (ΔE), step potential (ΔEs) and frequency (f ) parameters were optimized. The peak currents plotted in the range of 0.5 - 12.5 mg/L proparacaine exhibited two linear sections with a detection limit of 0.11 mg/L. The results for the determination of proparacaine on a pharmaceutical local anesthetic (Alcaine®) showed that relative standard deviation (RSD) and relative error (RE) were 4.1 and -2.0%, respectively. Selectivity has also been investigated and results showed recoveries of 5.0 mg/L proparacaine in the presen...Continue Reading

References

Sep 15, 1991·American Journal of Ophthalmology·J S Weiss, M B Goren
Jan 1, 1991·Journal of Pharmaceutical and Biomedical Analysis·A A BouklouzeG D Christian
Jul 1, 1994·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·J M BartfieldN Raccio-Robak
Dec 31, 2003·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Nianbing LiGuonan Chen
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May 3, 2005·Journal of Pharmaceutical and Biomedical Analysis·Zbigniew FijałekMałgorzata Warowna-Grześkiewicz
Mar 15, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Einosuke TanakaKatsuya Honda

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Citations

May 14, 2019·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Jinjin DangJialing Zhang
Feb 26, 2020·Critical Reviews in Analytical Chemistry·Solomiya PysarevskaLiliya Dubenska
Dec 4, 2019·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Mitsunobu TakemotoMasahiko Hara
Oct 27, 2020·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Mitsunobu TakemotoMasahiko Hara

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