PMID: 8587945Nov 1, 1995Paper

Determination of optical properties and blood oxygenation in tissue using continuous NIR light

Physics in Medicine and Biology
H LiuB Chance

Abstract

In this article, we introduce a simple method to characterize optical properties and blood oxygenation in tissue using spatially resolved, steady-state reflectance. The method considers multiple source-detector separations larger than 2 cm, i.e. 20 times the optical mean free path in tissue, and makes an approximation to linearize the relationship between the separation and reflectance. Simulation results show that errors of the algorithm due to the approximation are less than 10%. Using a calibration sample, we calculate from the slope and intercept the absorption and reduced scattering coefficients, mu a and mu's, of a tissue-like solution, and experimental results confirm the usefulness of the method for quantitation of haemoglobin saturation in tissue.

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Citations

May 6, 1998·BioFactors·L Salganicoff
Mar 17, 2011·European Journal of Applied Physiology·Christopher M BoppThomas J Barstow
Apr 5, 2011·Annals of Biomedical Engineering·Camille Vazquez-JaccaudMarija Strojnik
Dec 8, 2010·The Review of Scientific Instruments·Rebecca ReAlessandro Torricelli
Nov 10, 2009·Journal of Biomedical Optics·Xinmai YangLihong V Wang
Jun 3, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matthias L SchroeterD Yves von Cramon
Oct 31, 2006·NeuroImage·Matthias L SchroeterD Yves von Cramon
Sep 22, 2005·Technology in Cancer Research & Treatment·S Nioka, B Chance
Nov 6, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matthias L SchroeterD Yves von Cramon
Nov 18, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Andras EkeMárton Hajnal
Mar 21, 2002·Advances in Skin & Wound Care·A MatasH H Mantsch
Sep 8, 2017·Journal of Dental Research·C Y LinJ V Jokerst
Dec 15, 2011·Journal of Biophotonics·Julia L Sandell, Timothy C Zhu
Jun 18, 2016·Journal of Biomedical Optics·Antonio PifferiAlessandro Torricelli
May 7, 2005·Physics in Medicine and Biology·Andreea DimofteTimothy C Zhu
Jun 7, 2003·Applied Optics·Alois K PoppDavid A Weitz
Jan 5, 2002·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·R L BarbourC H Schmitz
May 7, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Thomas AlderliestenEsben T Petersen
Sep 5, 2017·Frontiers in Human Neuroscience·Vanessa ScarapicchiaJodie R Gawryluk
Dec 18, 2001·Journal of Applied Physiology·Maria Angela FranceschiniSergio Fantini

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