PMID: 11325079Apr 28, 2001Paper

Determination of optimal blood pressure for patients with IgA nephropathy based on renal histology

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Y OsawaF Gejyo

Abstract

To evaluate the optimal BP control for patients with IgA nephropathy (IgAN) based on the histologic severity of the nephropathy and the degree of renal dysfunction. We analyzed 332 consecutive renal biopsy specimens and clinical data from patients with IgAN. Patients were divided into three groups based on their BP at the time of biopsy: an optimal BP (SBP<120 mmHg and DBP<80 mmHg), a hypertensive BP (SBP > or = 140 mmHg and/or DBP > or = 90 mmHg), and an intermediate BP group. Each biopsy specimen was evaluated for mesangial proliferation, degree of sclerosis and/or hyalinosis of the arterioles and the interlobular artery using a semiquantitative method. Creatinine clearance and the percentage of sclerosed glomeruli were also determined. Both the degree of renal dysfunction and the histologic changes correlated significantly with BP, even in patients with a BP <140/90 mmHg. The patients with an optimal BP at the time of biopsy had significantly less histologic damage with respect to mesangial proliferation and vessel changes than those with an intermediate or hypertensive BP. In the patients with a hypertensive BP, the percentage of sclerotic glomeruli was significantly higher and the creatinine clearance was significantly low...Continue Reading

References

Jul 1, 1990·American Journal of Hypertension·S C Sommers, J Melamed
Oct 1, 1995·Hypertension·M MänttäriV Manninen
Jan 27, 1993·JAMA : the Journal of the American Medical Association·T V PernegerM Szklo
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Dec 2, 1999·Hypertension Research : Official Journal of the Japanese Society of Hypertension·H NakayaT Saruta

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Citations

Jun 16, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Judit NagyIstván Wittmann
Apr 19, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Atsuhiro KannoYutaka Imai
Nov 20, 2009·Kidney International·Rigas G Kalaitzidis, George L Bakris
May 24, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ryota IkeeSoichiro Miura
Dec 18, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ichiei NaritaFumitake Gejyo
Jun 22, 2007·Journal of the American Society of Nephrology : JASN·Toshiharu NinomiyaYutaka Kiyohara

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