Determination of oral bioavailability of curcuminoid dispersions and nanoemulsions prepared from Curcuma longa Linnaeus

Journal of the Science of Food and Agriculture
Pei Shan LuBing Huei Chen

Abstract

Curcuminoid from Curcuma longa Linnaeus has been demonstrated to be effective in anti-cancer and anti-inflammation. The objectives of the present study were to prepare curcuminoid dispersion and nanoemulsion from C. longa and determine their oral bioavailabilities in rats. After curcuminoid extraction using 99.5% ethanol, bisdemethoxycurcumin (BDMC), demethoxycurcumin (DMC) and curcumin were separated within 10 min by high-performance liquid chromatography using an Eclipse XDB-C18 column (Agilent, Palo Alto, CA, USA) and a gradient mobile phase of 0.1% aqueous formic acid and acetonitrile, with a flow rate of 1 mL min-1 , column temperature of 35 °C and detection wavelength of 425 nm. Curcuminoid nanoemulsion at a particle size of 12.1 nm and encapsulation efficiency 98.8% was prepared using lecithin, Tween 80 and water. A pharmacokinetic study in rats revealed that the parameters including Tmax , Cmax , t1/2 and the area under the curve were higher for curcuminoid nanoemulsions than for curcuminoid dispersion at the same dose employed for gavage administration, whereas, for intravenous injection, an opposite trend was shown. The oral bioavailabilities of BDMC, DMC, curcumin and total curcuminoids in nanoemulsion and dispersion...Continue Reading

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Citations

Aug 15, 2019·Nanomedicine·Francisco ArriagadaJavier Morales
Aug 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Raghavendhar R Kotha, Devanand L Luthria
Jan 27, 2019·Bioengineering & Translational Medicine·Maria JarvisSamir Mitragotri
Aug 11, 2019·Nutrients·Francesca PivariLaura Soldati
Apr 1, 2019·Veterinary World·Sobhy Abdel-ShafyMohammad Yahya Alshahrani
Aug 4, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Oi Jin TanUsha Sundralingam
Nov 11, 2021·Journal of the Science of Food and Agriculture·Li ZhaoAbdur Rehman

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