Determination of organoarsenicals in the environment by solid-phase microextraction-gas chromatography-mass spectrometry

Journal of Chromatography. a
B Szostek, J H Aldstadt

Abstract

The development of a method for the analysis of organoarsenic compounds that combines dithiol derivatization with solid-phase microextraction (SPME) sample preparation and gas chromatography-mass spectrometry (GC-MS) is described. Optimization focused on a SPME-GC-MS procedure for determination of 2-chlorovinylarsonous acid (CVAA), the primary decomposition product of the chemical warfare agent known as Lewisite. Two other organoarsenic compounds of environmental interest, dimethylarsinic acid and phenylarsonic acid, were also studied. A series of dithiol compounds was examined for derivatization of the arsenicals, and the best results were obtained either with 1,3-propanedithiol or 1,2-ethanedithiol. The derivatization procedure, fiber type, and extraction time were optimized. For CVAA, calibration curves were linear over three orders of magnitude and limits-of-detection were < 6.10(-9) M in solution, the latter a more than 400 x improvement compared to conventional solvent extraction GC-MS methods. A precision of < 10% R.S.D. was typical for the SPME-GC-MS procedure. The method was applied to a series of water samples and soil/sediment extracts, as well as to aged soil samples that had been contaminated with Lewisite.

Citations

Aug 2, 2008·Journal of the American Society for Mass Spectrometry·Jesse A ContrerasMilton L Lee
May 23, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Joe V WootenAntonia M Calafat
May 16, 2014·Environmental Science and Pollution Research International·K JaworekŁ Bratek
Jun 26, 2015·Environmental Science and Pollution Research International·Marianna CzaplickaMarta Bąk
Nov 20, 2012·Talanta·Janine RichterChristian Piechotta
Jul 8, 2016·Bulletin of Environmental Contamination and Toxicology·Alessandro SassoliniMaurizio Guidotti
Feb 24, 2001·Journal of Chromatography. a·J S Frit, M Macka
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Nov 20, 2001·Chemical Reviews·S D Richardson
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Jun 29, 1999·Analytical Chemistry·R E ClementC J Koester

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