Determination of parabens in human milk and other food samples by capillary electrophoresis after dispersive liquid-liquid microextraction with back-extraction

Food Chemistry
Usama AlshanaNilgün G Göğer

Abstract

Dispersive liquid-liquid microextraction (DLLME) with back-extraction was used prior to capillary electrophoresis (CE) for the extraction of four parabens. Optimum extraction conditions were: 200 μL chloroform (extraction solvent), 1.0 mL acetonitrile (disperser solvent) and 1 min extraction time. Back-extraction of parabens from chloroform into a 50mM sodium hydroxide solution within 10s facilitated their direct injection into CE. The analytes were separated at 12°C and 25 kV with a background electrolyte of 25 mM borate buffer containing 5.0% (v/v) acetonitrile. Enrichment factors were in the range of 4.3-10.7 and limits of detection ranged from 0.1 to 0.2 μg mL(-1). Calibration graphs showed good linearity with coefficients of determination (R(2)) higher than 0.9957 and relative standard deviations (%RSDs) lower than 3.5%. DLLME-CE was demonstrated to be a simple and rapid method for the determination of parabens in human milk and food with relative recoveries in the range of 86.7-103.3%.

References

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Citations

Dec 28, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Aysegul Kutluay BaytakMehmet Aslanoglu
Oct 6, 2018·Rapid Communications in Mass Spectrometry : RCM·Sung-Hee Cho, Han-Na Song
Jan 23, 2021·Analytical Methods : Advancing Methods and Applications·Shiuan Yih BehSaliza Asman
May 16, 2017·Journal of Chromatography. a·Mina FotouhiMohammad Taghi Naseri

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