PMID: 9431943Feb 12, 1998Paper

Determination of penicillin MICs for Streptococcus pneumoniae by using a two- or three-disk diffusion procedure

Journal of Clinical Microbiology
M R JacobsP C Appelbaum

Abstract

The potential for the use of the disk diffusion method to accurately predict penicillin MICs for Streptococcus pneumoniae was investigated with penicillin (6 microg), methicillin (5 microg), and oxacillin (1 microg) disks. A total of 183 S. pneumoniae isolates were tested by three MIC procedures (agar dilution, microdilution, and E-test). Regression analyses of the geometric mean of the three MIC results against (i) the sum of the zone diameters for methicillin, penicillin, and oxacillin disks; (ii) the sum of the zone diameters for methicillin and penicillin disks; and (iii) each of the three individual zone diameters were performed. Calculated MICs were determined from each of these regression analyses and compared to the mean reference MICs. A high level of correlation was obtained with both the two- and the three-disk procedures (r = 0.97), with essential agreement rates (+/-1 doubling dilution) between MICs calculated by the three-disk procedure and the two-disk procedure and the mean reference MICs of 98.4 and 98.9%, respectively. No major or very major errors were obtained with the two- or three-disk procedures. The accuracy of the disks used individually was lower (r = 0.84 to 0.93). However, oxacillin and methicillin d...Continue Reading

References

Oct 5, 1978·The New England Journal of Medicine·M R JacobsR Austrian
Jul 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M R Jacobs
Jul 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P C Appelbaum
Jul 1, 1992·Diagnostic Microbiology and Infectious Disease·M R JacobsA Bolmström
Apr 1, 1990·Clinical Microbiology Reviews·K P Klugman
Nov 1, 1986·Journal of Clinical Microbiology·J M SwensonC Thornsberry
Nov 1, 1985·Journal of Clinical Microbiology·R F D'AmatoC Thornsberry
Apr 1, 1981·The Journal of Antimicrobial Chemotherapy·M R JacobsP A Anton
Jan 1, 1997·Antimicrobial Agents and Chemotherapy·E L FasolaM R Jacobs

❮ Previous
Next ❯

Citations

Oct 1, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Rosemol Varghese, Balaji Veeraraghavan
May 29, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter C Appelbaum
Sep 24, 2020·Antibiotics·Adam KmeckGregory R Wiedman
Jun 19, 2018·The Journal of Antimicrobial Chemotherapy·Stefano ManciniErik C Böttger
Apr 20, 1999·Journal of Chemotherapy·M R Jacobs

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.