Determination of pharmaceutical residues in drinking water in Poland using a new SPE-GC-MS(SIM) method based on Speedisk extraction disks and DIMETRIS derivatization

The Science of the Total Environment
Magda CabanPiotr Stepnowski

Abstract

The presence of pharmaceuticals in drinking water, even at very low concentrations, has raised concerns among stakeholders such as drinking-water regulators, governments, water suppliers and the public, with regard to the potential risks to humans. Despite this, the occurrence and the fate of pharmaceuticals in drinking waters of many countries (e.g. in Poland) remains unknown. There is a lack of sufficiently sensitive and reliable analytical methods for such analyses and a need for more in-depth hydrogeological analysis of the possible sources of drug residues in drinking water. In this paper, a multi-residual method for the simultaneous determination of seventeen human pharmaceuticals in drinking waters has been developed. Large-volume extractions using Speedisk extraction disks, and derivatization prior to GC-MS-SIM analysis using a new silylating agent DIMETRIS were applied. The method detection limits (MDLs) ranged from 0.9 to 5.7ng/L and the absolute recoveries of the target compounds were above 80% for most analytes. The developed method was successfully applied in the analysis of the target compounds in drinking water collected in Gdansk (Poland), and of the 17 pharmaceuticals, 6 compounds were detected at least once. D...Continue Reading

References

Mar 23, 2005·Trends in Biotechnology·Oliver A JonesNick Voulvoulis
May 6, 2005·Environmental Science & Technology·Henning Prommer, Pieter J Stuyfzand
Dec 26, 2006·The Science of the Total Environment·Jacob GibsRobert Lee Lippincott
Mar 28, 2007·Analytica Chimica Acta·H F De BrabanderH Noppe
Feb 19, 2008·The Science of the Total Environment·Patrick M PalmerChia-Yang Chen
Apr 2, 2008·Chemosphere·M Silvia Díaz-Cruz, Damià Barceló
Dec 3, 2010·Water Research·Maria Huerta-FontelaFrancesc Ventura
Feb 7, 2012·Environmental Pollution·D J LapworthR S Ward

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Citations

Jan 29, 2016·Journal of Pharmaceutical and Biomedical Analysis·Anna Białk-BielińskaPiotr Stepnowski
Mar 13, 2016·Journal of Pharmaceutical and Biomedical Analysis·Alan PuckowskiPiotr Stepnowski
Sep 26, 2016·Chemosphere·Ting Yien FangIrniza Rasdi
Dec 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Naiara M F M SampaioBruno J G Silva
Jan 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniel WoleckiJolanta Kumirska
Jul 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elena SartiLuisa Pasti
Aug 8, 2020·The Science of the Total Environment·Piotr StepnowskiMagda Caban
Feb 16, 2021·Environmental Science and Pollution Research International·Joane M M CorrêaRobson J C F Afonso
Feb 24, 2021·Environmental Science and Pollution Research International·Ze-Hua LiuYu Liu
Feb 10, 2019·Chemosphere·Heloise Beatriz QuesadaRosângela Bergamasco
May 1, 2021·Environmental Science and Pollution Research International·Wulan KoagouwCorina Ciocan

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