Determination of phthalates in fish fillets by liquid chromatography tandem mass spectrometry (LC-MS/MS): A comparison of direct immersion solid phase microextraction (SPME) versus ultrasonic assisted solvent extraction (UASE)

Chemosphere
Antonella PanioFrancesco Saliu

Abstract

Due to the increasing presence of plastic and plastic associated contaminants in the aquatic environments, the monitoring of this contamination in fish products and the understanding of possible human health implications is considered urgent. However, data are still relatively scarce, mostly due to the methodological challenges in the chemical analysis: these contaminants are ubiquitous and procedural contamination from the laboratory is frequent. In this work, we compared solid-phase microextraction (SPME) to ultrasonic assisted solvent extraction (UASE) as sample preparation methods for the liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) determination of phthalates in fish fillets. UASE was carried out with an acetone-hexane (1:1) solution and according to a reference procedure aimed to obtain the exhaustive extraction of the target analytes. SPME was carried out by applying C18 fibers in direct immersion mode and by using water/methanol 20:80 mixture to desorb the aliquot required for the analysis. Overall, SPME displayed an improved control of the background contamination and enabled lower LOQs. Precision, calculated as relative standard deviation (RSD) on replicates of a reference sample, was below 24%...Continue Reading

Citations

Feb 1, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Juan-Juan GaoMing-Qi Wang
May 16, 2021·Marine Pollution Bulletin·Stefanie ReinoldMay Gómez
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Łukasz SobczakKrzysztof Goryński

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