Determination of phthalic acid, mono-(2-ethylhexyl) phthalate and di-(2-ethylhexyl) phthalate in human plasma and in blood products

Journal of Chromatography
H Shintani

Abstract

Pretreatment for the determination of phthalic acid, mono-(2-ethylhexyl) phthalate (MEHP) and di-(2-ethylhexyl) phthalate (DEHP) in human serum or plasma, and the determination of these compounds in blood products by high-performance liquid chromatography was studied. The amount of phthalic acid, MEHP and DEHP, migrated into blood products from a flexible bag, was studied. About 0.1% of DEHP in a flexible bag was found to have migrated into human platelet plasma. Most of the MEHP and phthalic acid detected in human platelet plasma was not derived from the flexible bag but was produced by enzymatic hydrolysis of the migrated DEHP. The amount of DEHP eluted into blood products from the flexible bag differed, depending upon storage time, storage temperature, etc.

References

Apr 7, 2009·Toxicology and Applied Pharmacology·Nikki GillumNarine Sarvazyan
Jul 19, 2003·Transfusion·Christoph BuchtaMarkus Dettke
Dec 1, 2011·Toxicological Research·Du Yeon BangByung-Mu Lee
Sep 2, 2014·Toxicology Mechanisms and Methods·Pınar Erkekoglu, Belma Kocer-Gumusel

Related Concepts

Human plasma
Blood product
In Vivo NMR Spectroscopy
Diethylhexyl Phthalate
Phthalates
Phthalate
Spectrophotometry, Ultraviolet
High Pressure Liquid Chromatography Procedure
Phthalic acid
Ultrafiltration

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