Determination of piroxicam and its major metabolites in the plasma, urine and bile of humans by high-performance liquid chromatography

Journal of Chromatography
P A Milligan


A simple and sensitive liquid chromatographic method with ultraviolet detection is described for the determination of the nonsteroidal anti-inflammatory drug piroxicam and its major metabolites in human plasma, urine and bile. Separation of these components occurs on a reversed phase C10CN column with a mobile phase consisting of acetonitrile-water-sodium dihydrogenphosphate solution. The detection limit of the assay was 50 ng/ml with intra- and inter-assay coefficients of variation for piroxicam of the order of 2 and 5%, respectively. The assay linearity was good (typically r = 0.9999). This method can be readily utilised for clinical pharmacokinetic and mass-balance studies.


Jan 1, 1993·European Journal of Clinical Pharmacology·P A MilliganB Whiting
Mar 1, 1995·Journal of Pharmaceutical and Biomedical Analysis·M T MayaJ A Morais
May 1, 1995·Journal of Pharmaceutical and Biomedical Analysis·L EdnoM Galtier
Jun 5, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·S Radhofer-Welte, P Dittrich
Jul 20, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·A BakkaliF Vicente
Jul 20, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·A D de JagerA F Hundt
Aug 23, 2001·Journal of Pharmaceutical and Biomedical Analysis·A DoliwaP Ygartua
Jun 7, 2002·Journal of Pharmaceutical and Biomedical Analysis·S DadashzadehN Rezagholi
Jul 31, 2003·Journal of Veterinary Pharmacology and Therapeutics·H L HeebR P Hunter
Nov 1, 1995·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J SchmidH Wachsmuth

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