PMID: 11849915Feb 19, 2002Paper

Determination of piroxicam by solid-phase spectrophotometry in a continuous flow system

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
M I Pascual-RegueraMaría Soledad Castro Ruiz


A simple flow injection UV spectrophotometric method was developed for the determination of piroxicam. The method is based on its transient retention and concentration on Sephadex DEAE-A-25 anion-exchange gel beads packed in the flow cell and the continuous monitoring of its native absorbance on the solid phase at 354 nm. The sample was injected into a 0.1 M NaCl carrier stream at pH 9.5 by using a simple monochannel FIA manifold. When the analytical signal reached a maximum value, piroxicam was eluted from the solid support by means of a desorbing solution (0.2 M, pH 4.5). The response of the sensor was linear in the concentration range 0.5-10 microg ml(-1) with a R.S.D. (%) of 1.8, a detection limit (3 sigma criterion) of 0.1 microg ml(-1) and a sampling rate of 13 h(-1). Application to the analysis of pharmaceutical samples testifies to the utility of this sensor. The accuracy of the proposed method was better than 5%.


May 1, 1995·Journal of Pharmaceutical and Biomedical Analysis·L EdnoM Galtier
Oct 1, 1993·Journal of Pharmaceutical and Biomedical Analysis·C Sánchez-PedreñoJ Rodriguez
Aug 23, 2001·Journal of Pharmaceutical and Biomedical Analysis·A DoliwaP Ygartua
May 1, 1985·Talanta·K Yoshimura, H Waki

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