Determination of protein allergenicity: studies in rats

Toxicology Letters
A H Penninks, L M Knippels

Abstract

For the safety evaluation of genetically engineered crops the potential allergenicity of the newly introduced protein(s) has become an important issue. There is, however, no universal and reliable test system for the evaluation of the allergenic potency of food products. The best known allergy assessment proposal is the careful stepwise process using the IFBC/ILSI decision tree. Unfortunately, the described tests are not always conclusive, especially if the gene source coding for the protein has no history of dietary use and/or an unknown history in terms of allergenicity. The further testing warranted should in particular be focused on the prediction of the sensitizing potential of the novel protein, for which animal models are considered to be needed. In this paper the results are summarized of a promising food allergy model developed in Brown Norway (BN) rats. The results demonstrate that BN rats can be sensitized orally to the various allergenic food proteins tested, resulting in significant antigen-specific IgE responses, without the use of adjuvants. Upon oral challenge of previously sensitized animals, local and systemic immune-mediated effects, such as increased gastrointestinal permeability and decreased breathing freq...Continue Reading

References

Jan 1, 1979·International Archives of Allergy and Applied Immunology·R PauwelsM Van Der Straeten
Jan 1, 1990·International Archives of Allergy and Applied Immunology·J SteinmannW Müller-Ruchholtz
Jul 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M W TurnerS Strobel
Dec 1, 1980·The Journal of Experimental Medicine·S J Challacombe, T B Tomasi
May 1, 1995·Allergy·O Scheiner, D Kraft
Jan 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H A AtkinsonK Miller
Jan 1, 1996·Critical Reviews in Food Science and Nutrition·S L Taylor, S B Lehrer
Jan 1, 1996·Critical Reviews in Food Science and Nutrition·D D MetcalfeR L Fuchs
Feb 4, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J HiltonI Kimber
May 30, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L M KnippelsG F Houben
Feb 9, 1999·The Journal of Allergy and Clinical Immunology·X M LiH A Sampson
Jul 10, 1999·Die Nahrung·J M Wal
Oct 3, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L M KnippelsG F Houben
Mar 21, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R J DearmanI Kimber

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Citations

Apr 4, 2002·Allergy·Y Vandenplas, B Hauser
Feb 8, 2003·Environmental Health Perspectives·Léon M J Knippels, André H Penninks
Jun 27, 2003·Environmental Health Perspectives·Ian KimberRicki M Helm
Apr 18, 2014·Clinical and Translational Allergy·Gregory S LadicsJean-Michel Wal
Aug 20, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K L BøghC B Madsen
Nov 1, 2012·Journal of Immunotoxicology·Na SunHuilian Che
Apr 17, 2012·Regulatory Toxicology and Pharmacology : RTP·Sishuo CaoKunlun Huang
Dec 13, 2006·Methods : a Companion to Methods in Enzymology·Jonathan D de JongeHenk van Loveren
Jan 31, 2004·Current Opinion in Allergy and Clinical Immunology·Ricki M Helm, A Wesley Burks
Sep 9, 2005·World Journal of Gastroenterology : WJG·Xu-Dong JiaXiao-Guang Yang
Apr 29, 2004·Journal of Agricultural and Food Chemistry·Sugey R Sinagawa-GarcíaOctavio Paredes-López

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